Effects of non-pharmacological or pharmacological interventions on cognition and brain plasticity of aging individuals.

Brain aging and aging-related neurodegenerative disorders are major health challenges faced by modern societies. Brain aging is associated with cognitive and functional decline and represents the favourable background for the onset and development of dementia. Brain aging is associated with early and subtle anatomo-functional physiological changes that often precede the appearance of clinical signs of cognitive decline. Neuroimaging approaches unveiled the functional correlates of these alterations and helped in the identification of therapeutic targets that can be potentially useful in counteracting age-dependent cognitive decline. A growing body of evidence supports the notion that cognitive stimulation and aerobic training can preserve and enhance operational skills in elderly individuals as well as reduce the incidence of dementia. This review aims at providing an extensive and critical overview of the most recent data that support the efficacy of non-pharmacological and pharmacological interventions aimed at enhancing cognition and brain plasticity in healthy elderly individuals as well as delaying the cognitive decline associated with dementia

Mixed-Criticality Systems on Commercial-Off-the-Shelf Multi-Processor Systems-on-Chip

Avionics and space industries are struggling with the adoption of technologies like multi-processor system-on-chips (MPSoCs) due to strict safety requirements. This thesis propose a new reference architecture for MPSoC-based mixed-criticality systems (MCS) - i.e., systems integrating applications with different level of criticality - which are a common use case for aforementioned industries. This thesis proposes a system architecture capable of granting partitioning - which is, for short, the property of fault containment. It is based on the detection of spatial and temporal interference, and has been named the online detection of interference (ODIn) architecture. Spatial partitioning requires that an application is not able to corrupt resources used by a different application. In the architecture proposed in this thesis, spatial partitioning is implemented using type-1 hypervisors, which allow definition of resource partitions. An application running in a partition can only access resources granted to that partition, therefore it cannot corrupt resources used by applications running in other partitions. Temporal partitioning requires that an application is not able to unexpectedly change the execution time of other applications. In the proposed architecture, temporal partitioning has been solved using a bounded interference approach, composed of an offline analysis phase and an online safety net. The offline phase is based on a statistical profiling of a metric sensitive to temporal interference’s, performed in nominal conditions, which allows definition of a set of three thresholds: 1. the detection threshold TD; 2. the warning threshold TW ; 3. the α threshold. Two rules of detection are defined using such thresholds: Alarm rule When the value of the metric is above TD. Warning rule When the value of the metric is in the warning region [TW ;TD] for more than α consecutive times. ODIn’s online safety-net exploits performance counters, available in many MPSoC architectures; such counters are configured at bootstrap to monitor the selected metric(s), and to raise an interrupt request (IRQ) in case the metric value goes above TD, implementing the alarm rule. The warning rule is implemented in a software detection module, which reads the value of performance counters when the monitored task yields control to the scheduler and reset them if there is no detection. ODIn also uses two additional detection mechanisms: 1. a control flow check technique, based on compile-time defined block signatures, is implemented through a set of watchdog processors, each monitoring one partition. 2. a timeout is implemented through a system watchdog timer (SWDT), which is able to send an external signal when the timeout is violated. The recovery actions implemented in ODIn are: • graceful degradation, to react to IRQs of WDPs monitoring non-critical applications or to warning rule violations; it temporarily stops non-critical applications to grant resources to the critical application; • hard recovery, to react to the SWDT, to the WDP of the critical application, or to alarm rule violations; it causes a switch to a hot stand-by spare computer. Experimental validation of ODIn was performed on two hardware platforms: the ZedBoard - dual-core - and the Inventami board - quad-core. A space benchmark and an avionic benchmark were implemented on both platforms, composed by different modules as showed in Table 1 Each version of the final application was evaluated through fault injection (FI) campaigns, performed using a specifically designed FI system. There were three types of FI campaigns: 1. HW FI, to emulate single event effects; 2. SW FI, to emulate bugs in non-critical applications; 3. artificial bug FI, to emulate a bug in non-critical applications introducing unexpected interference on the critical application. Experimental results show that ODIn is resilient to all considered types of faul

Imaging multi-age construction settlement behaviour by advanced SAR interferometry

This paper focuses on the application of Advanced Satellite Synthetic Aperture Radar Interferometry (A-DInSAR) to subsidence-related issues, with particular reference to ground settlements due to external loads. Beyond the stratigraphic setting and the geotechnical properties of the subsoil, other relevant boundary conditions strongly influence the reliability of remotely sensed data for quantitative analyses and risk mitigation purposes. Because most of the Persistent Scatterer Interferometry (PSI) measurement points (Persistent Scatterers, PSs) lie on structures and infrastructures, the foundation type and the age of a construction are key factors for a proper interpretation of the time series of ground displacements. To exemplify a methodological approach to evaluate these issues, this paper refers to an analysis carried out in the coastal/deltaic plain west of Rome (Rome and Fiumicino municipalities) affected by subsidence and related damages to structures. This region is characterized by a complex geological setting (alternation of recent deposits with low and high compressibilities) and has been subjected to different urbanisation phases starting in the late 1800s, with a strong acceleration in the last few decades. The results of A-DInSAR analyses conducted from 1992 to 2015 have been interpreted in light of high-resolution geological/geotechnical models, the age of the construction, and the types of foundations of the buildings on which the PSs are located. Collection, interpretation, and processing of geo-thematic data were fundamental to obtain high-resolution models; change detection analyses of the land cover allowed us to classify structures/infrastructures in terms of the construction period. Additional information was collected to define the types of foundations, i.e., shallow versus deep foundations. As a result, we found that only by filtering and partitioning the A-DInSAR datasets on the basis of the above-mentioned boundary conditions can the related time series be considered a proxy of the consolidation process governing the subsidence related to external loads as confirmed by a comparison with results from a physically based back analysis based on Terzaghi's theory. Therefore, if properly managed, the A-DInSAR data represents a powerful tool for capturing the evolutionary stage of the process for a single building and has potential for forecasting the behaviour of the terrain-foundation-structure combination

Biokinetics Of microbial consortia using biogenic sulfur as a novel electron donor for sustainable denitrification

In this study, the biokinetics of autotrophic denitrification with biogenic S0 (ADBIOS) for the treatment of nitrogen pollution in wastewaters were investigated. The used biogenic S0, a by-product of gas desulfurization, was an elemental microcrystalline orthorhombic sulfur with a median size of 4.69 µm and a specific surface area of 3.38 m2/g, which made S0 particularly reactive and bioavailable. During denitritation, the biomass enriched on nitrite (NO2–) was capable of degrading up to 240 mg/l NO2–-N with a denitritation activity of 339.5 mg NO2–-N/g VSS·d. The use of biogenic S0 induced a low NO2–-N accumulation, hindering the NO2–-N negative impact on the denitrifying consortia and resulting in a specific denitrification activity of 223.0 mg NO3–-N/g VSS·d. Besides Thiobacillus being the most abundant genus, Moheibacter and Thermomonas were predominantly selected for denitrification and denitritation, respectively

Biovalorization of Lignocellulosic Waste

The swift and successful transition towards a fossil fuel-free economy is amongst the most complex challenges ever faced by humanity, implicating intricate connections and trade-offs with the so-called water–energy–food nexus [...